I recently saw an article by @dnlongen on potential uses for OpenDNS:
Detecting Malware Through DNS Queries
It made me want to take advantage of OpenDNS on my home network. OpenDNS allows users to configure DNS servers that block requests for many types of content, including known malicious domains.
Because OpenDNS is owned by Cisco, you may want to consider if it offers the level of privacy you need. It's safe to assume that they log every request and provide the information to others. But does a real internet super-villain rely on their DNS server? At least we know who owns OpenDNS – who owns your VPN?